While traditionally less common than vertebrate models, invertebrate
models, such as fruit flies (Drosophila melanogaster) and roundworms (Caenorhabditis
elegans), are increasingly utilized in psychiatric research. Despite their
evolutionary distance from humans, these models offer several advantages,
including genetic tractability, short generation times, and well-characterized
neural circuits.
Researchers can manipulate the genomes of invertebrates to study the role
of specific genes implicated in psychiatric disorders, providing insights into
conserved molecular pathways underlying mental illness. Invertebrates also
exhibit behaviors relevant to psychiatric conditions, such as learning, memory,
aggression, and responses to stress.
Moreover, invertebrate models allow for high-throughput screening of
potential psychiatric medications and elucidation of drug mechanisms. By
leveraging these models, psychiatry researchers can identify novel therapeutic
targets, screen for compounds with psychoactive properties, and explore the
neurobiological basis of psychiatric phenotypes.
Overall, invertebrate models complement vertebrate models in psychiatric
research, offering valuable insights into the genetic, molecular, and neural
mechanisms underlying mental disorders.
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